The most significant associations with AAA discovered in candidate gene studies are: (1) SORT1 (lipid metabolism) (Jones et al., 2013); (2) IL6R (inflammation) (Harrison et al., 2013); (3) LPA (lipid metabolism); (4) AGTR1 (Renin angistenin system) (Jones et al., 2008); (5) TGFBR2 (TGFB signaling) (Biros et al., 2011); (6) MMP3 (Degradation of ECM) (Yoon et al., 1999); (7) MTHFD1 (methionine metabolism) (Hinterseher et al., 2011); (8) LRP5 (lipid metabolism) (Boucher et al., 2003). Here, TGFB1 is linked to triple-A syndrome.