On the other hand, Notarianni recently proposed a role for GR signaling in the initiation and development of AD, implicating over-activation of GR with hypercortisolemia in promoting amyloid beta (Aβ) production that leads to Aβ deposition and associated neuroinflammation (Notarianni, 2013). Here, NR3C1 is linked to adrenal gland hyperfunction.