NR3C1 and Cognitive impairment: Therefore, this review facilitates the understanding of the following: (1) involvement of both GR and ACh receptors in modulating cognition, thus providing a palliative approach for pharmaceutical interventions as these receptors are discussed in many research papers as a route to therapeutic intervention; (2) an interactive platform to mark the holistic consequences of cognitive impairment converging from varied neurological deficits; and finally; (3) an interactive role of glucocorticoids in the development of cognitive dysfunction and vulnerability of the hippocampus to such exposure.