More specifically, hypersecretion of glucocorticoid, or A-beta-altered HPA axis function, have been implicated in hippocampal impairment in AD (Hibberd et al., 2000; Brureau et al., 2013) Additionally, elevated glucocorticoid levels and impaired GR signaling are associated with HPA dysfunction, resulting in cognitive decline in elderly subjects (Issa et al., 1990; Lupien et al., 1994; Bizon et al., 2001; Mizoguchi et al., 2009). This evidence concerns the gene NR3C1 and Alzheimer disease.