NOS2 and Parkinson disease: Furthermore, the augmentation of iNOS (Inducible nitric oxide synthase) observed in SN and striatum of PD (Hunot et al., 1996) suggests that the toxicity originating both from cytokines/chemokines and inflammation-derived oxidative stress could contribute to dopaminergic neuronal degeneration and progression of the disease (Orr et al., 2005; Wilms et al., 2007).