TNF and Bloom syndrome: A generalized derangement of CD4+ lymphocytes, monocytes and neutrophils and an overproduction of proinflammatory cytokines related to Th1 cells, such as interferon-gamma (IFNγ), tumor necrosis factor (TNF)α, interleukin (IL)1, IL6, IL8 and IL12, have been observed in BS [16].