CBLC and breast neoplasm: We also found that siRNA reagents designed to target CBLC caused olaparib sensitisation in MCF7 cells as well as in a second breast tumour cell line model, HS578T (Figure 2C,D,E), suggesting that these effects were neither restricted to the method of RNA interference used nor to the MCF7 cell line model used in the original genome wide shRNA screen.