Several studies, based on ectopic expression of Synpo2 in prostate cancer PC3 cells, an invasive cell type with very low levels of Synpo2 protein expression due to a hemizygous deletion [11], indicate Synpo2 suppresses cell invasion in vitro, and inhibits tumor development and metastasis in vivo [11, 12]. This evidence concerns the gene SYNPO2 and prostate cancer.