It is plausible to view P-protein of Hepatitis B structurally and functionally as a fusion of the TP and telomere-associated protein pair of Streptomyces—with its N-terminal TP domain corresponding to the TP of Streptomyces and its polymerase domain corresponding to the telomere-associated protein of Streptomyces. This evidence concerns the gene OCA2 and hepatitis B virus infection.