ICAM1 and serum lipopolysaccharide activity: Ameliorated PMN recruitment to brain tissue has been demonstrated during endotoxemia in ICAM-1-deficient mice, similar to our findings in which an anti-ICAM-1 antibody reduced PMN adhesion to hCMEC/D3, suggesting an important role for β2-integrin-ICAM-1 interactions in PMN adhesion to CMEC [41].