Recent literature supports the notion that key hypertension genes and pathways, such as the Na+‐K+‐2Cl−‐cotransporter 1 (NKCC1) (Cho et al, 2012) and angiotensin‐converting enzyme 1 (ACE1) (Lee et al, 2012), are epigenetically regulated in relation to hypertension. This evidence concerns the gene ACE and hypertensive disorder.