These results are consistent with previous evidence linking SH2B3 to a range of signaling cascade activities such as cytokine signaling (Takizawa et al, 2008) as well as recent findings on the role of T lymphocytes in hypertension through a feed‐forward mechanism: modest degrees of blood pressure elevation lead to T‐cell activation, which in turn promotes inflammation and further blood pressure elevation (Marvar et al, 2010; Kirabo et al, 2014). This evidence concerns the gene SH2B3 and hypertensive disorder.