Individual mutations in some HOXA genes as HOXA1, HOXA2, HOXA11, and HOXA13 are known to cause respectively Athabaskan brainstem dysgenesis syndrome (OMIM #601536), microtia, hearing impairment and cleft palate (OMIM #612290), radioulnar synostosis with amegakaryocytic thrombocytopenia (OMIM #605432), and hand-foot-genital syndrome (HFGS, OMIM#140000) or Guttmacher syndrome (GUTTS OMIM #176305) [1]. This evidence concerns the gene HOXA11 and hand-foot-genital syndrome.