In in vitro experiments, the expression of an anti-apoptotic protein in endothelial cells (Bcl-2) is also stimulated.14 VEGF is expressed in colorectal cancer, and its expression correlates with tumor progression and poor prognosis.7 That is why anti-angiogenic agents for the treatment of colorectal carcinoma have been developed. The gene discussed is BCL2; the disease is colorectal carcinoma.