Other more direct methods, such as VEGF determinations of blood or the use of new markers of angiogenesis in endothelial cells and CD105 expressed on the endothelium of carcinoma cells and underexpressed in normal endothelial cells,25 could help to elucidate the role of angiogenesis in perforated colon cancer. The gene discussed is VEGFA; the disease is colonic neoplasm.