NKX2-1 and lung adenocarcinoma: Conversely, some reports showed that NKX2-1 may suppress lung adenocarcinoma progression via impeding TGF-β-induced epithelial-to mesenchymal transition (EMT) due to increased E-cadherin expression [6] and occuludin targeted by NKX2-1 impeded migration and induced aknoikis in lung cancer cells [7].