NKX2-1 and neoplasm: Interestingly, p53-WT patients with high-NKX2-1 mRNA and high-p53 mRNA tumours exhibited more favourable OS and RFS compared with those with low-NKX2-1 mRNA tumours (NKX2-1: HR, 0.48, P = 0.022 for OS; HR, 0.40, P = 0.003 for RFS; p53: HR, 0.43, P = 0.009 for OS; HR, 0.42, P = 0.003 for RFS); however, p53-mutant patients with high-NKX2-1 mRNA and high-p53 mRNA tumours had more unfavourable OS and RFS than those with low-NKX2-1 mRNA tumours (NKX2-1: HR, 7.41, P = 0.001 for OS, HR, 2.71, P = 0.010 for RFS; p53: HR, 3.74, P = 0.004 for OS; HR, 2.13, P = 0.032 for RFS; Table 2).