IKBKB and neoplasm: However, patients with high-IKKβ mRNA, high-IKKβ protein, and nuclear p65 tumours exhibited poorer OS and RFS than those with low-IKKβ mRNA, low-IKKβ protein, and cytoplasmic p65 tumours (OS: HR, 1.93, P = 0.001 for IKKβ mRNA; HR, 2.68, P = 0.008 for IKKβ protein; HR, 3.24, P = 0.003 for nuclear p65; RFS: 1.91, P = 0.004 for IKKβ mRNA; HR, 2.01, P = 0.017 for IKKβ protein; HR, 2.14, P = 0.010 for nuclear p65; Table 2).