TOPK plays a role in the development and proliferation of many types of cancers, such as breast, lung, and colon cancers and melanoma, and it is associated with poor prognosis in multiple types of cancer [24-25, 28, 42-44]; however, no studies of the expression of TOPK in prostate cancer have yet been reported. The gene discussed is PBK; the disease is malignant colon neoplasm.