Sequencing the 28,440 base pair region containing VAMP1 (+/-20 kb) in 300 Alzheimer’s disease cases and 300 controls (95% power to detect all variants with MAF > 1%), we identified 10 variants, 5 of which were subsequently genotyped in the remaining case-control series (10,842 samples). This evidence concerns the gene VAMP1 and early-onset autosomal dominant Alzheimer disease.