Here we have identified a strong association of common VAMP1 polymorphisms with VAMP1 cerebellar transcript levels in Alzheimer’s disease and control brains, with the strongest correlation at the 3′ end of the gene with increased VAMP1 expression (rs7390 and rs12964, all p < 2.4×10-7). Here, VAMP1 is linked to early-onset autosomal dominant Alzheimer disease.