Moreover, VAMP1 +/- mice had a reduced pool of soluble Aβ40 and Aβ42 in the brain of 10-day old VAMP1+/- compared with wildtype mice (Figure 2C), albeit that is impossible to determine from these brain extracts whether this reduction in Aβ is due to a reduction in Aβ secretion or Aβ production.We next sought to determine whether decreased VAMP1 expression could have a protective role against developing Alzheimer’s disease. This evidence concerns the gene VAMP1 and early-onset autosomal dominant Alzheimer disease.