VAMP1 and early-onset autosomal dominant Alzheimer disease: Here we report an in-depth study of the relationship between VAMP1 polymorphisms and transcriptional VAMP1 expression in the brain of Alzheimer’s disease patients and cognitively healthy controls, the correlation between VAMP1 protein expression and neuronal Aβ secretion using primary neurons derived from mice heterogeneously expressing VAMP1 and a case-control association study of 4,667 Alzheimer’s disease patients and 6,175 controls of Caucasian European descent.