Finally, a recent meta-analysis by Varghese et al. suggested that density has a polygenic basis that likely overlaps at least partially with the genetic basis of breast cancer [28]; although not specifically focusing on which genes and SNPs drive this association, two of the strongest associations were observed with rs10995190 and rs10509168, two SNPs in gene ZNF365 which have also been associated with breast cancer risk [63]. This evidence concerns the gene ZNF365 and breast carcinoma.