Hence, T-cell receptor signalling (LCP2, FYB, FYN, LAT, TRBC1), T-cell cytotoxicity (RAB27A, IL7R, CTSC, IL12RB1, CTSH), target cell apoptosis by cytotoxic T-cells and natural killer cells (GZMB, GZMA, LYZ) and immune surveillance (CD58 and genes of the MHCII class; e.g. HLA-DPA1, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1) were up-regulated in the CHO-sensitive tumours. The gene discussed is IL12RB1; the disease is neoplasm.