As shown in Additional file 5: Figure S4, CNAs of RXRB were found mostly as gains in the stable and intermediate groups (14/15), but were often found as losses or unchanged in the unstable group (24/28), consistent with the tumour-suppressing functions of RXRB. Copy-numbers of VPS13B and NCOA2 were mostly unchanged in the stable and intermediate groups (15/15 and 14/15, respectively), but were frequently gained in the unstable group (15/28 and 19/28, respectively), consistent with the oncogenic functions of these genes. The gene discussed is VPS13B; the disease is neoplasm.