VPS13B and Cohen syndrome: The 51 genes include the following biologically relevant genes: RXRB, a member of the retinoid X receptor family of nuclear receptors, which plays a critical role in the regulation of growth and differentiation in normal and tumour cells [31], VPS13B, which is mutated in gastric and colorectal cancers, and in Cohen syndrome with high microsatellite instability [32] and is coamplified with MYC in breast cancers [33], and NCOA2, encodes nuclear receptor coactivator 2, related to the function of nuclear hormone receptors and amplified or overexpressed in prostate cancers [34].