This inhibition was quantified by measuring the percentage of positive CD31 staining area against the total tumor area by the visual approximation technique (1.9% for HB-002.1 vs. 6.2% for PBS in the Colo-205 model; 0.7% for HB-002.1 vs. 7.1% for PBS in the A549 model) (Table 4). Here, PECAM1 is linked to neoplasm.