However due to target limitation (only targeting VEGF-A) as well as relatively poor tissue penetration because of its large size, the overall impact of bevacizumab in prolonging survival was very limited [22,23], with 5-year survival generally between 5% and 8% [23], suggesting that VEGF-A blockade alone may not be good enough to completely prevent tumor angiogenesis and corresponding tumor growth. This evidence concerns the gene VEGFA and neoplasm.