We then selected four SNPs (NFKB1 rs28362491 ins/delATTG, rs4648068 A/G, RELA rs7119750 C/T, and REL rs842647 G/A) from the canonical pathway of NF-κB and investigated their clinical relevance in relation to the development of sepsis and MODS. This evidence concerns the gene REL and Sepsis.