Although it has been reported to have a regulatory influence on NFKB1 gene expression and is known to be associated with cancer [35-39], acute respiratory distress syndrome [40], periodontitis [41], autoimmune and inflammatory diseases [42], and inflammatory bowel diseases [43], the functional polymorphism rs28362491 (also known as the −94 insertion/deletion ATTG polymorphism in the promoter of NFKB1) was not shown to be associated with risk of sepsis and MODS in our study. The gene discussed is NFKB1; the disease is cancer.