Therefore, DRGMDD = DRGMDD − pre − (DRGMDD − pre ∩ DRGMDD − post) were deemed to be the true MDD-related DRGs (termed DRGMDD that included FOSL1, MEF2A, HNF1A, IRF1, JUN, SOX9, SRF, TFAP4, TFCP2, TLX2, HLF, and ZNF423). This evidence concerns the gene IRF1 and major depressive disorder.