A number of the miRNAs in this signature have been previously characterized in cervical cancer and other diseases, such as miR-218, which downregulates survivin (BIRC5) in nasopharyngeal carcinoma [29], and miR-21, which regulates PTEN expression in hepatocellular carcinoma [30]. The gene discussed is BIRC5; the disease is nasopharyngeal carcinoma.