Since the GM-CSF protein is species-specific, and the efficacy of gene therapeutic constructs was tested in tumor-inoculated animals, we prepared two constructs, one of which contained the mouse gm-csf gene (mGM-CSF) and was designed for model experiments in mice, whereas another one contained human GM-CSF and was designed for testing of toxicity and subsequent clinical trials as well as for comparative analysis of the functional properties of human and mouse GM-CSF containing constructs. This evidence concerns the gene PPP1R3A and neoplasm.