PICALM and Alzheimer disease: Two established risk factors for AD identified by GWAS were nominally associated in our study but with an opposite direction of association, rs3851179 in PICALM (P = 2.37 × 10−3, OR = 1.87) [40,41] and rs6701713 in CR1 (P = 0.01, OR = 0.42) [40,42].