HMGCR and familial hypercholesterolemia: This is the specific inhibitor in the reaction of HMG-CoA reductase because monacolin K has the same chemical structure as the ‘statin drugs’, a group of drugs used in hypercholesterolemia treatment and potent inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [34].