SNP rs463426-A and rs131654-A, located downstream of HIC2 and upstream of UBE2L3, was identified as susceptibility variants with SLE in a Han Chinese population (P = 1.48 × 10−16 and 2.99 × 10−16, respectively) [14]. The gene discussed is UBE2L3; the disease is systemic lupus erythematosus.