In inflammatory conditions, high serum IGFBP-2 levels are associated with elevated cytokine interleukin (IL)-6 [22,24-26], another prognostic factor for glioblastoma [9,27] that negatively regulates serum albumin level by increasing catabolism and down-regulating hepatic synthesis, which further worsens the nutritional status of the patient. Here, IGFBP2 is linked to glioblastoma.