Since artificial targeting of PrP to the Golgi results in intracellular retention of α2δ-1 [15], D177N/M128 may also impair VGCC transport and function in CGNs, contributing to the motor dysfunction of Tg(FFI), as in Tg(PG14) and Tg(CJD) mice. Here, PRNP is linked to Creutzfeldt Jacob disease.