In regard to NF-κB, we first observed in HapMap that rs1598859 and rs7665090 are not in complete linkage disequilibrium (LD) (D′ = 0.77 and R2 = 0.31; SNPs are on the same block according to D′ value but are not in phase according to R2) and then found from our GWAS data that the MAFs were 0.355 in patients with SSc and 0.382 in controls (uncorrected P value = 0.2). The gene discussed is NFKB1; the disease is systemic sclerosis.