As expected, the results showed that B lymphocytes (tumor fraction) from VAR-CLLs showed a higher level of HSP90B1 expression than B lymphocytes from WT-CLLs (P = 0.001), and also from the normal cells from the same patients (VAR-CLLs) (P < 0.001) (Additional file 3: Figure S1). The gene discussed is HSP90B1; the disease is neoplasm.