In current study, we found that treatment with rosuvastatin prevented (1) CM-mediated caspase-3 activation, (2) CM-induced increase of ratio of Bax/Bcl-2, (3) CM-induced an increase in TUNEL staining cells, indicating that rosuvastatin prevents apoptosis in CIN. The gene discussed is CASP3; the disease is cervical squamous intraepithelial neoplasia.