Finally, the immunochemical data also showed that the expression of Bcl-2, Cyclin D1 and COX-2 was reduced to a far greater extent in the Ad23-treated group and the Af23-treated group than compared to the vehicle-treated group (Figure 4E), indicating that these two FGFR1 inhibitors also induced tumor-cell apoptosis in H460 xenografts. This evidence concerns the gene CCND1 and neoplasm.