In the present study, the data revealed that the compounds Ad23 and Af23 suppressed the phosphorylation of FGFR1 in H460 tumor tissues, thereby inhibited the downstream phosphorylation of ERK and AKT, and reduced the expression of BCL-2, COX-2, and Cyclin D1 (Figure 4). This evidence concerns the gene AKT1 and neoplasm.