MART-1 sensitized PBMC released IFNγ when stimulated with the target cells loaded with Melan-A/MART-1-epitope (modified and native) and, importantly, they recognized in a MHC restricted fashion HLA-A*0201+MART1+, but not HLA-A*0201+MART1− and HLA-A*0201−MART1+ tumor cells as evaluated by ELIspot assay (Figure 3). The gene discussed is MLANA; the disease is neoplasm.