Although some reports demonstrate the anti-tumor effects of IGFBP-7 including cell growth inhibition [7,40], senescence [12,41,42], and apoptosis [12,42,43], our study is evident that the down-regulation of IGFBP-7 in invasive HNSCC cell lines which show EMT feature. Here, IGFBP7 is linked to head and neck squamous cell carcinoma.