ESR1 and breast cancer: Breast cancer methylation data and RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) and show that SOX11 methylation is more abundant in estrogen recptor (ER) positive tumors (n=460) compared to ER negative tumors (n=139) (Figure 4A) with a strong anti-correlation between methylation and expression in each CpG site (Figure 4B and Table 2).