On the other hand, not only proinflammatory cytokines, e.g. tumor necrosis factor-alpha – (TNF-α), the interleukins (IL) and interferon-gamma (IFN-gamma), but also anti-inflammatory cytokines are released by CNS and peripheral-derived immune cells and play a powerful role in depression [9]. The gene discussed is TNF; the disease is depressive symptom measurement.