Changes in mitochondrial fission may also affect the pathophysiology of stroke and seizure, in which Drp1 is a therapeutic target.9, 10, 11 Furthermore, AD, seizures, and stroke are associated with increased synaptic transmission and impaired metabolism,31, 46, 47, 48 and changes in mitochondrial fission might contribute to or synergize with these alterations. Here, DNM1L is linked to Alzheimer disease.