TNFRSF10B and glioblastoma: Therefore, the aim of the present study is to evaluate a rational combination of two novel anti-cancer agents in preclinical models of glioblastoma, that is, the TRAIL-receptor 2 (TRAIL-R2)-specific antibody Drozitumab to directly trigger apoptosis and the Smac mimetic BV6 to lower the threshold for apoptosis induction by antagonizing IAP proteins.