PAX3 and melanoma: Although there were no overall differences in post-translational modifications of PAX3 in melanoma cells compared to melanocytes, our data did reveal a difference in acetylation between primary melanoma cells compared to metastatic melanoma and melanocytes and significant down-regulation of the PAX3E transcript in melanoma cells compared to normal melanocytes and it is possible that this down-regulation could result in the differences seen in downstream target gene regulation.