PAX3 and melanoma: Our analysis of PAX3 downstream targets in melanocytes and melanoma cells showed that while a subset of target genes are similarly regulated by PAX3 in melanoma and melanocyte cells, particularly those that regulate maintenance of an undifferentiated ‘stem cell’ phenotype, PAX3 differentially regulates target genes that are associated with cell proliferation and survival in melanoma cells relative to melanocytes [8].