TGFB1 and neoplasm: They release growth factors (e.g., SDF-1α, VEGF, HGF, EGF, FGFs, TGF-β, PDGF), pro-tumorigenic inflammatory signals and matrix metalloproteases promoting angiogenesis, tumor cell proliferation and invasiveness (Lebret et al, 2007; Liao et al, 2009; Ostman and Augsten, 2009; Sadlonova et al, 2009; Erez et al, 2013; Gialeli et al, 2014).