In particular, the crucial role of CAF-released growth factors such as hepatocyte growth factor/scatter factor (HGF), transforming growth factor-β (TGF-β) or basic fibroblast growth factor (bFGF) in promoting invasive behaviour of breast tumor cells has been demonstrated (Giulianelli et al, 2008; Jedeszko et al, 2009; Stuelten et al, 2010; Cao et al, 2013). This evidence concerns the gene FGF2 and breast neoplasm.