HMGB1 and myeloid sarcoma: Factors mainly related to study design may well explain the discrepancies observed with the present study: inclusion of a subgroup of RRMS patients during relapse, lack of further stratification of the MS group into RRMS and SPMS patients for HMGB1 comparisons among groups, or lumping non-inflammatory neurological controls and healthy controls within a unique control group [8].