To clarify the cause-effect relationship between translocation of TRPM2 and Ca2+ influx, we compared the time course of the tumor cell-induced translocation of TRPM2 and Ca2+ influx at 5 min after stimulation with B16F10 cells and found that TRPM2 remained at intracellular granules (Supplementary Figure S1) when the tumor cell-induced Ca2+ influx occurred (Fig. 1a and 2e). This evidence concerns the gene TRPM2 and neoplasm.