The independent prognostic value of pretreatment serum CEA levels remains in patients with gastric cancer after adjustment for covariates (i.e., age, Borrmann type, CA199, depth of invasion, sex, histology, liver metastasis, location, nodal involvement, TNM stage, tumor size, lymphatic invasion, peritoneal metastasis; shown in Table 4). Here, CEACAM5 is linked to metastasis.