AFDN and endometrioid adenocarcinoma: The H-score of AF-6/afadin was significantly associated with histological grade (between grade 1 and 2 cases, and between grade 1 and 3 cases, P < 0.01) and myometrial invasion (between cases with no invasion and cases with a myometrial invasion depth of more than 50%, P < 0.01) in endometrioid adenocarcinoma (Figure 1b, c).