Loss of nfkb1 promotesageing-associated chronic liver disease (CLD), characterized by steatosis,neutrophillia, fibrosis, hepatocyte telomere damage and HCC.Nfkb1S340A/S340Amice carrying a mutationdesigned to selectively disrupt p50:p50:HDAC1 complexes are more susceptible to HCC;by contrast, mice lacking S100A9 express reduced neutrophil chemokines and areprotected from HCC. The gene discussed is S100A9; the disease is hepatocellular carcinoma.