NFKB1 and hepatocellular carcinoma: A remaining question was the nature of the neutrophil-mediated pro-tumourmechanism that is opposed by hepatocellular nfkb1. This is likely to bemultifactorial given the vast array of cytotoxic molecules, inflammatorymediators and mitogenic factors released by neutrophils37.However, when examining human HCC tissue we were intrigued by the juxtapositionof neutrophil-rich inflammatory foci with hepatocytes positive for8-hydroxyguanosine, the latter being a biomarker for oxidative DNA damage (Fig. 5a).