Finally, although there is no obvious humanmodel for loss of p50 homodimers, there are common polymorphisms in the humanNFKB1 gene that have been genetically linked with inflammatory disease.In particular, the –94 del/ins (rs28362491)-promoted polymorphism, whichis predicted to result in reduced expression of p50, is associated with increasedrisk for HCC and for other cancers including breast, prostate, gastric, colorectaland oral50, 51, 52, 53. Here, NFKB1 is linked to hepatocellular carcinoma.