Ofnote, both the nfkb1−/−BM>WTand WTBM>nfkb1−/− animals wereconsidered too sick for use in longer-term studies that would have confirmed thehepatocyte-specific actions ofnfkb1−/− in HCC; this phenotypemay be related to our recent report thatnfkb1−/− cells are highlysusceptible to radiation-induced senescence22. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.