TAC1 and disease of the tendon: Mediators of neurogenic inflammation—i.e., inflammation arising from the release of neuropeptides from afferent neurons[142]—including substance P[143, 144], calcitonin gene related peptide (CGRP)[145], glutamate[81], and the proangiogenetic cytokine, VEGF[43, 44, 71, 82], have also been associated with tendinopathy.