In studies based on methods, which only allowed simultaneous quantification of a limited number of prespecified mRNA molecules or proteins, this review found several markers of tissue remodelling to be differentially expressed/represented in human tendinopathy, most notably collagen I and III, MMP-1, -3, -9, and -13, TIMP-1, and VEGF. The gene discussed is TIMP1; the disease is disease of the tendon.