Interestingly, single ADAMTS4 knockout mice have no apparent phenotype although when knocked out combinatorially with Adamts1, mice die of post-natal renal failure [34]; the current study shows adamts4 is absent in the zebrafish genome, collectively suggesting ADAMTS4 to be less important during vertebrate development, whereas adamts1 was strongly expressed in zebrafish kidney. Here, ADAMTS4 is linked to kidney failure.