ADAMTS1 and Renal insufficiency: Interestingly, single ADAMTS4 knockout mice have no apparent phenotype although when knocked out combinatorially with Adamts1, mice die of post-natal renal failure [34]; the current study shows adamts4 is absent in the zebrafish genome, collectively suggesting ADAMTS4 to be less important during vertebrate development, whereas adamts1 was strongly expressed in zebrafish kidney.