EGFR and neoplasm: In another study, Sia et al. [19] analyzed a series of 149 archived formalin-fixed tumor tissues and reported the presence of two distinct transcriptional classes: the so-called inflammation class characterized by activation of inflammatory signaling pathways and the so-called proliferation class characterized by activation of oncogenic signaling pathways (including EGFR and MET), the latter being associated with a worse outcome.