More importantly, inhibition of TLR4 by bilateral microinjection into the PVN of the SHR rats delays the progression of hypertension; reduces cardiac hypertrophy; attenuates PICs, iNOS, and NFκB, as well as NE levels; and improves anti-inflammatory IL-10 levels within the PVN. The gene discussed is NFKB1; the disease is cardiac hypertrophy.