AGT and hypertensive disorder: Several mechanisms that have been shown to exist in hypertension include excessive vasoconstriction, commonly involving the endogenous peptides, angiotensin II and endothelin, or deficient vasodilatation, often involving nitric oxide (NO), dysregulation of adrenergic mechanisms [2], increase in the total peripheral resistance either due to increase in the contractile responses or a decrease in relaxant responses in resistance arteries [3].