TLR4 and hypertensive disorder: It is noteworthy that although these studies show suppression of inflammation in the end-organs, none of the studies were able to point out the role of the brain in hypertension Given our current findings that TLR4 is dramatically upregulated within the PVN and that the TLR4 blockade attenuates MAP, our results suggest a vital role played by hypothalamic TLR4 in hypertensive response.