To analyze which signaling pathways are targeted and disrupted in thyroid carcinoma cells by sorafenib, we assessed levels of phosphorylated members of the MAP kinase family and of receptor tyrosine kinases after sorafenib treatment for 10 minutes in BHT101, ML1, SW1736 and HTh7 cells. This evidence concerns the gene NTRK1 and thyroid gland carcinoma.