As shown in Figure 4, MAb 5261-muIg significantly inhibited B cell migration into spleens of naïve Balb/c mice, while Kramer and colleagues recently demonstrated that CXCL13 neutralization with MAb 5261-muIg in a NOD mouse model of Sjogren’s syndrome caused reduction in salivary gland inflammation by inhibiting B cell recruitment into submandibular gland tissue [38]. Here, CXCL13 is linked to Sjogren syndrome.